Inhalation
Our inhalation team is experienced with a wide range of technical capabilities using multiple technology platforms combined with expertise in complex drug delivery, routinely helping customers overcoming formulation and production challenges.
Magle Chemoswed is a founding member of the Swedish leading inhalation Contract Research Organization (CRO), Medicon Valley Inhalation Consortium (MVIC) and provides solid state chemistry on a wide range of inhalation projects with our specialist team, and state of the art facilities.
Our scientists have a comprehensive experience and competence within the dry powder inhalation field. We can make a real difference when it comes to critical aspects like the special characterization demands or formulation challenges that often occur in dry inhalation formulations.
As part of helping our customers meet the challenges of inhalation, we regularly draft protocols for improved handling of processing steps like micronization where we also offer hands-on fluidized jet mill micronization in small scale (2,5”).
Our experience and support extend to solutions for better handling of post micronisation material to improve powder properties. We can both design processes and provide equipment (PowdeCCTM system) intended to actively regain full crystallinity post processing and thus minimizing inherent issues like poor chemical stability and/or deaggregation.
We know how challenging it can be to successfully develop an inhalation product. Our team of experts has the answers and can provide the support to drive your project to success.
Our services include
- Assessment of critical properties related to product performance using all essential characterization techniques
- Determination of relaxation kinetics versus relevant storage conditions
- Restoration of crystallinity, i.e., active conditioning
- Production of inhalation grade particle size distribution using fluidized jet mill
- Support for patent applications
| Capabilities |
|---|
| Reversed engineering of dry powder inhalation products |
| Jet mill micronisation using 2.5” kit in dedicated safety cabinet with PSD support |
| Mixing of micronized substances in close to particle-to-particle level |
| Evaluation of powder flow using a Pharmacopeia approved equipment |
| Detection of minute amount of surface amorphicity using complementary methods |
| Conditioning (restoration of crystallinity) of process induced surface amorphicity |
| Comprehensive solid-state characterization of both substances and formulations |
| Salt and polymorph screening and selection |
| Crystallization of “difficult-to -crystallize” compounds |
| IP and Regulatory support |
| RH and temperature-controlled facilities with uninterrupted power supply |
| Equipment |
|---|
| DSC/MTDSC |
| TGA |
| XRPD (GMP option) |
| IR (microscopy possibility) |
| Raman (microscopy) |
| LALLS (GMP option) |
| SSA (based on BET principle) |
| Powder flow (Angle of Repose) |
| Pycnometer |
| GVS |
| Isothermal microcalorimetry (GMP option) |
| Fluidized jet mill (small scale, 2.5”) |
| Micro mixing kit |
| Crystallization kit (convection based) |
| NMR |
| SXRD |
Talk to our specialist
Lars-Erik Briggner
Lars-Erik has a master degree in Chemistry, Physics
and Mathematics, and a PhD in Physical Chemistry.
His background is in dry powder formulation, solid
form selection and solid state analyses.
