Crystallization

The properties of a crystalline compound are significantly different from that of an amorphous one and it is vital to also perform the early phase investigation on the representative form to avoid serious misinterpretations. Crystallisation development and scale-up is always a challenge since the product properties must meet up to the intended functionality, stability and safety of the final product. Our teams have more than 30 years of experience in the field and are leading experts in the area.

API solid form

Our team of experts are highly experienced in supporting well-designed crystallization processes and supporting your development by providing deeper insight into the solid-state properties of your drug substance helping you to ensure high product purity and the consistent delivery of the desired crystal modification.

Since the particle size distribution of the product depends upon both the solvent/solute system used and process parameters and equipment properties, crystallization can be employed to engineer particles precisely and with the right properties that ensure the optimum performance of the drug product. By applying our practical know how, theoretical understanding and innovative technical approaches  we provide direct support in this area. Integrated into our small scale approach is not only traditional solvent based methodology but we perform also complementary investigations, based on alternative technologies, and thus significantly increase the success rate of providing you with seeds or a manufacturing protocol.

Capabilities

DSC / MDSC
TGA
XRPD
IR (microscopy possibility)
Raman (microscopy) LALLS (Malvern 3000, Malvern Mastersizer) 
BET
Powder flow
Pycnometer
GVS
TAM (microcalorimetry) Isothermal or Scanning
SEM
EDS-SEM
LM
NMR
SXRD
Reverse engineering
Micronisation
Micro mixing
Crystallinity 
Amorphicity
Salt & polymorph screening and selection
Crystallisation of “difficult-to-crystallise” compounds

In addition to the above list, Magle Chemoswed AB performs a broad range of tailor-made investigation services related to material characterization, understanding, troubleshooting and synthesis of gram and kilo quantities.


Talk to one of our specialists

Thomas Larsson
Thomas has 30 years of experience from working within global pharmaceutical industry. He is expert in solid state characterization of pharmaceutical APIs and formulations and is Solid State Manager within Magle Chemoswed AB since 2019.

Contact

Magle Chemoswed AB

Agneslundsvägen 27
212 15 Malmö, Sweden
info@maglechemoswed.com
+46 (0)40 38 33 00

Magle Chemoswed and Logos are registered trademarks of Magle Chemoswed.